John Frater

Professor John Frater is a leading academic at the Nuffield Department of Medicine, University of Oxford, where he leads the HIV Reservoir and Cure Group. His work focuses on advancing HIV cure research through clinical trials and laboratory studies, with a strong emphasis on translational outcomes.

• Key affiliations: Rockefeller University, Imperial College, Gates Foundation, NIH REACH Martin Delaney Collaboratory
• Clinical trials: RIO ($10M), RIVER, PITCH, SPARTAC, HEATHER

Research Interests include:

• Understanding HIV persistence and developing strategies for eradication
• Immunology of HIV reservoirs and antiviral responses
• Genetic studies of HIV to inform therapies
• Immune modulation and vaccination approaches for HIV cure
• Interactions between HIV and co-infections like SARS-CoV-2

Recent Publications highlight his expertise in:

• HIV-specific broadly neutralizing antibodies (bNAbs)
• ART-free viral control mechanisms
• Immune dynamics post-treatment interruption
• Impact of metabolic factors on immune responses
• Comparative studies of SARS-CoV-2 variants and vaccines