Jochen Walter

Jochen Walter is a Professor at the University of Bonn's Department of Neurology. His research investigates molecular mechanisms underlying Alzheimer's disease pathogenesis, focusing on amyloid-beta metabolism, neuronal signaling pathways, and neurodegeneration. The laboratory employs molecular, biochemical, and cell biological techniques using in vitro and in vivo models.

Research interests include Alzheimer's disease mechanisms, neuronal metabolism dysfunction, and amyloid-beta aggregation pathways. Studies explore functional roles of genetic factors in neurodegeneration initiation and progression, aiming to identify therapeutic targets.

Selected publications examine neuroinflammatory cross-seeding of amyloid deposits, phosphorylation-dependent oligomer toxicity, microglial exosome secretion, and extracellular phosphorylation in aggregate formation.