معرفی
Dr. Jo Simpson serves as Mass Spectrometry Specialist and Researcher at the University of Edinburgh's School of Neurological and Cardiovascular Sciences. Current roles include Principal Investigator on an MRC-funded cancer therapeutics project and Researcher on a BBSRC initiative advancing mass spectrometry applications for health research.
Research focuses on analytical biochemistry applications in liver pathophysiology and hormonal regulation:
- Development of novel LC-MS/MS methods for steroid/thyroid hormone quantitation
- Mechanistic studies of paracetamol-induced liver injury and inflammation
- Investigation of neutrophil temporal functions in liver repair processes
- Analysis of gut-liver axis dysregulation in steatotic disease progression
- Exploration of long COVID interactions with reproductive endocrinology
Recent publications demonstrate methodological innovation in mass spectrometry applied to complex biomedical questions, with strong emphasis on translational relevance to liver disease and hormonal disorders. Work frequently employs mouse models and cross-species comparative approaches.
Active grants include MRC funding for ENPP1 inhibitor development in cancer and BBSRC support for next-generation mass spectrometry applications in lifelong health research. These projects facilitate interdisciplinary collaboration across Edinburgh's research institutes.
The research environment provides advanced mass spectrometry resources within the School of Neurological and Cardiovascular Sciences, supporting method development and biological application studies through partnerships with clinical and basic science teams.
