Jimmy Lloyd Holder Jr

Dr. Jimmy Lloyd Holder Jr. is an Assistant Professor at Baylor College of Medicine, affiliated with the Jan and Dan Duncan Neurological Research Institute. His roles include clinical care in pediatric neurology and research in neurodevelopmental disorders. He holds MD and PhD degrees from the University of Texas Southwestern and completed residencies at Baylor College of Medicine, specializing in Pediatrics and Neurology.

Education:

• B.A. in Biology, Johns Hopkins University (1996)
• M.D. and Ph.D. in Genetics, University of Texas Southwestern (2005)
• Pediatrics Residency, Baylor College of Medicine (2012)
• Child Neurology Fellowship, University of California San Francisco (2007)

Research Interests: Focuses on developing personalized therapies for neurodevelopmental disorders using cell-based screens, mouse models, and iPSC-derived neurons. Key areas include SHANK3 and SYNGAP1 research, genetic modifiers, and translational approaches for conditions like Phelan-McDermid syndrome.

Grants & Awards:

• NIH R01NS120980 (2021-2026): Investigating SHANK3 post-translational regulation
• NINDS R03NS120078 (2020-2022): Sulfamidase protein stability modifiers
• Doris Duke Clinical Scientist Development Award (2017-2021)
• Philip R. Dodge Young Investigator Award (2015)

Labs & Teams: Leads research at the Duncan NRI, collaborating on projects involving neurogenetics and translational neuroscience. Co-organizes conferences for Phelan-McDermid Syndrome Foundation initiatives.