Jie Zheng

Jie Zheng is Professor of Ophthalmology at UCLA's David Geffen School of Medicine, where his research integrates chemical, computational, structural, and systems biology to develop therapeutics targeting visual system signaling pathways. His laboratory focuses on structure-based drug discovery and repositioning for ocular diseases.

Dr. Zheng's work centers on Wnt signaling modulation and steroid responses in trabecular meshwork biology and limbal stem cell maintenance. His laboratory systematically investigates how small molecules and proteins can regulate signal transduction pathways implicated in glaucoma and corneal disorders, with emphasis on structural mechanisms driving therapeutic development.

Analysis of his 2022-2025 publications reveals dominant themes: Wnt pathway manipulation (inhibitors/activators), trabecular meshwork responses to corticosteroids and pollutants, and extracellular vesicle therapies for ocular surface regeneration. His research consistently bridges structural insights with therapeutic applications for glaucoma and stem cell deficiency.

Dr. Zheng leads a multidisciplinary research team at UCLA advancing ophthalmic drug discovery through structural biology and computational approaches. While specific advising activities and grant details are not provided in available materials, his laboratory maintains active investigation into disease mechanisms and therapeutic targeting.