Jiayi Huang

Jiayi Huang, MD, MSCI is a Professor of Radiation Oncology at Washington University School of Medicine, where he serves as Chief of the CNS/Gamma Knife Service and Associate Director of the Brain Tumor Center at Siteman Cancer Center.

Dr. Huang's educational background includes:

• BA in Biochemistry from Brandeis University (2001)
• MD from University of Massachusetts Medical School (2007)
• Internship at University of Massachusetts Medical School (2008)
• Residency in Radiation Oncology at William Beaumont Hospital (2012)
• Master of Science in Clinical Investigation from Washington University in St. Louis (2019)

Dr. Huang specializes in Neuro-oncology with a research focus on developing clinical and translational studies for central nervous system malignancies. His work aims to reduce neurocognitive decline from radiotherapy while improving outcomes for brain tumor patients. He has expertise in molecular imaging, glioma research, and cancer stem cells, with particular emphasis on glioblastoma and other CNS tumors. His research spans from basic mechanisms to clinical applications, with a strong translational focus.

His recent publications demonstrate a strong focus on innovative radiation therapy approaches, including Gamma Knife radiosurgery, hippocampal-avoidance techniques, and novel combination therapies for glioblastoma. His work shows consistent progression toward more personalized and precise radiation treatments with emphasis on preserving neurocognitive function while maintaining tumor control.

Dr. Huang has received several professional recognitions:

• Teacher of the Year Award from the Department of Radiation Oncology at Washington University (2017)
• Best Doctors in St. Louis (2017, 2018, 2019)

As principal investigator, Dr. Huang leads multiple investigator-initiated phase I and phase II trials for glioblastoma and relapsed meningiomas. His clinical practice encompasses phase 0/1 clinical trials, brain tumors, skull base tumors, and spinal tumors. He collaborates extensively with neurosurgery, medical oncology, and imaging specialists through the Brain Tumor Center and Siteman Cancer Center, contributing to multidisciplinary approaches to brain tumor management.

Dr. Huang is affiliated with several key research programs including the Institute of Clinical and Translational Sciences (ICTS), the Bursky Center for Human Immunology & Immunotherapy Programs (CHiiPs), and the Brain Tumor Center, where he contributes to multidisciplinary approaches to brain tumor management and research.