معرفی
Jeremy Van Raamsdonk is an Associate Professor in the Department of Neurology and Neurosurgery at McGill University and a Scientist in the Metabolic Disorders and Complications Program at the Research Institute of the McGill University Health Centre (RI-MUHC). Embedded within the Centre for Translational Biology, his laboratory focuses on the genetics of aging and neurodegeneration, leveraging the nematode C. elegans to dissect how mitochondrial function, oxidative stress and innate immunity dictate lifespan and resilience.
Research Focus:
- Molecular mechanisms that extend healthy lifespan (geroscience)
- Mitochondrial signalling pathways (UPRmt, ROS, dynamics)
- Neuroprotective strategies for Parkinson’s and Huntington’s diseases
- Translational workflows from worm discoveries to mammalian pre-clinical models
His recent publications (2021-2023) converge on the concept that mild mitochondrial stress activates adaptive transcriptional programs—via ATFS-1, DAF-16/FOXO and p38 MAPK—that not only extend life but also protect against proteotoxic stress in neurodegenerative disease models. Exercise, endosomal trafficking proteins and redox systems emerge as modifiable nodes that can recapitulate these benefits.
Scientific Awards:
No specific honours or awards were detailed in the provided text; citations and h-index metrics (h-index ≈ 45) attest to substantial scholarly impact.
Grants & Collaborations:
While explicit grant numbers are not listed, his multi-author publications with cross-institutional teams (Harvard, UBC, Northwestern, Emory, etc.) indicate robust national and international funding and collaboration.
Laboratory & Teams:
Van Raamsdonk heads an active research group within the RI-MUHC Metabolic Disorders and Complications Program; trainees include post-doctoral fellows, graduate students and technicians working on C. elegans genetics, mammalian exercise physiology and high-throughput longevity assays.
