Jens Fielitz

Prof. Dr. Jens Fielitz serves as a DZHK Professor for Molecular Cardiology and Muscular Proteostasis at Ernst-Moritz-Arndt University Greifswald's Faculty of Medicine, Department of Internal Medicine B. He leads a translational research group within Research Cluster III focused on cardiac and skeletal muscle pathophysiology.

His research centers on the ubiquitin proteasome system (UPS) and its role in cardiac diseases, pathological remodeling, and inflammation-induced muscle wasting. Key investigations include MuRF protein regulation, PKD1 kinase signaling, and protein homeostasis disruption in critical illness. His work bridges molecular mechanisms to therapeutic strategies for heart failure and ICU-acquired weakness.

Analysis of his 2015-2023 publications reveals consistent focus on inflammatory pathways (NLRP3/IL-1β, TGF-β), transcription factors (TFEB), and E3 ligases (MuRF1) in muscle atrophy. Major themes include sepsis-induced cardiomyopathy, pressure overload responses, and skeletal muscle wasting mechanisms across critical care and cardiovascular contexts.

Prof. Fielitz actively mentors master's students and medical doctoral candidates through his lab's open positions. His research receives substantial funding from Deutsche Forschungsgemeinschaft (DFG), Deutsches Zentrum für Luft- und Raumfahrt (DLR), European Space Agency (ESA), Max-Delbrück-Centrum (MDC), Charité - Universitätsmedizin Berlin, Berlin Institute of Health (BIH), and European Regional Development Fund (ERDF).

He directs the Molecular Cardiology and Muscular Proteostasis Research Group in Research Cluster III, utilizing advanced molecular and cellular facilities to investigate cardiac remodeling and muscle wasting mechanisms. His team maintains active collaborations across German cardiovascular research networks including DZHK.