معرفی
Professor Jen-Tsan Ashley Chi holds multiple appointments at Duke University, including in Molecular Genetics and Microbiology, Biomedical Engineering, Integrative Immunobiology, Medicine, Radiation Oncology, Pharmacology and Cancer Biology, and Cell Biology. He is a member of the Duke Cancer Institute.
Education:
- Postdoctoral Research, Stanford University (Biochemistry)
- PhD, Stanford University
- MD, National Taiwan University
His research focuses on functional genomic approaches to cancer nutrient signaling and stress adaptations. Key areas include:
- Genetic determinants of ferroptosis in renal, breast, and ovarian cancers
- Discovery of the mammalian stringent response pathway mediated by MESH1
- Genomic analysis of red blood cell transcriptomes for doping detection and disease mechanisms
Recent studies highlight MESH1's role in oxidative stress protection and the anti-tumor effects of its genetic removal. His work has identified >10-fold miRNA changes in stored red blood cells with implications for blood transfusion practices.
Scientific Awards & Grants:
- NIH grants for thioredoxin derivatives and ferroptosis protection
- NCI-funded Duke PRIME Cancer Research Program
- DoD grant for renal cancer therapy
- ACS Institutional Research Grant
Leadership: Director of Duke's Hematology & Transfusion Medicine training program. Current research integrates genomic analysis, stress response pathways, and translational applications in cancer and blood disorders.
