Jeffrey L. Benovic

Jeffrey L. Benovic, PhD serves as the Thomas Eakins Endowed Professor in Cancer Biology within the Department of Biochemistry & Molecular Biology at Sidney Kimmel Medical College, Thomas Jefferson University. His research program investigates fundamental mechanisms of G protein-coupled receptor (GPCR) signaling and its pathological implications in cancer and neurological disorders.

Core research domains include:

• Regulation of GPCR signaling through GRKs and arrestins
• CXCR4-mediated cancer metastasis pathways
• Chemosensation mechanisms using C. elegans models
• Structural analysis of signaling complexes via crystallography

Employing proteomics, RNA interference, and biophysical approaches, his work targets therapeutic interventions for metastatic cancers and receptor-related pathologies through multidisciplinary molecular investigations.