Jeff S. Abramson

Jeff S. Abramson is a Professor in the Department of Physiology at the University of California, Los Angeles (UCLA), School of Medicine. He joined UCLA in 2005 after postdoctoral training at Imperial College London under So Iwata. His research focuses on membrane transport proteins, particularly their structures, functions, and roles in diseases. Key areas include sodium/glucose symporters (vSGLT), voltage-dependent anion channels (VDAC), and mitochondrial transport mechanisms.

• Education:
• PhD from Uppsala University, Sweden

Research Interests:
Dr. Abramson's lab investigates membrane transport proteins responsible for critical biological functions like ion regulation and metabolite import. They use structural biology (X-ray crystallography, cryo-EM) and biophysical methods to overcome challenges in membrane protein study. Collaborative efforts aim to resolve structures of channels and transporters, with applications in pharmacology due to their role as drug targets.

Selected Funding:
- NIH R35GM135175 (2020–2024): Cellular sugar transport mechanisms in disease
- NIH R01GM124783 (2017–2021): Glycobiology and pathogenic transporters

Lab Focus:
Interdisciplinary approaches to membrane protein crystallization, structural analysis, and functional dynamics. Key techniques include lipidic bicelle systems and microED crystallography.