Jean-Pierre Mothet

Jean-Pierre Mothet is a CNRS Director of Research and Team Leader at Université Paris-Saclay, with affiliations at ENS Paris-Saclay and previous roles at Aix Marseille University and University of Oxford. His work focuses on gliotransmission, NMDA receptor dynamics, and D-amino acids in neuroscience.

• Habilitation à Diriger des Recherches (University of Bordeaux, 2008)
• PhD in Neuroscience (University Pierre & Marie Curie, 1996)
• BSc in Neuroscience (University Claude Bernard, 1992)

Mothet's research explores astrocytic signaling, synaptic physiopathology, and the role of D-serine in NMDA receptor activation. He has pioneered tools for studying gliotransmission and implicated glial cells in neurodegenerative disorders.

His publications span neuroscience, neurochemistry, and computational biology, with recent work on D-amino acid transporters and synaptic calcium signaling. Articles frequently address gliotransmission mechanisms and their therapeutic implications.

• 2019 International Research Center on D-Amino Acids Scientific Committee
• 2018 Senior Research Visiting Fellow, Jesus College, Oxford
• 2015 FRM Team Award
• 2013 France Alzheimer Award
• 2012 France-Berkeley Award

Mothet has secured major grants from FRM, ANR, and SERVIER, with ongoing editorial roles at BMC Biology, Neuropharmacology, and Frontiers journals. His teams study glial cell dynamics in synaptic dysfunction and neurodegeneration.