Jean E. Lewis

Jean E. Lewis, M.D. is a distinguished pathologist specializing in anatomic pathology at the Mayo Clinic in Rochester, Minnesota. She is affiliated with the Department of Laboratory Medicine and Pathology, Division of Anatomic Pathology at the Mayo Clinic College of Medicine.

Dr. Lewis received her medical degree from Mayo Medical School in 1983 and completed her residency and fellowship training at Mayo Clinic. Her educational background includes a BA in Biology and Physiology from the University of Minnesota (1979), followed by residency in Anatomic and Clinical Pathology and fellowship in Surgical Pathology at Mayo Clinic.

Dr. Lewis is a leading expert in head and neck pathology with a particular focus on salivary gland tumors, laryngeal pathology, and surgical pathology. Her research has significantly contributed to the understanding of various head and neck malignancies, including mucoepidermoid carcinoma, salivary duct carcinoma, and sinonasal tumors. She has published extensively on the clinicopathologic features, immunohistochemical characteristics, and molecular genetics of these conditions, with over 100 publications spanning several decades.

Analysis of Dr. Lewis's recent publications reveals a strong emphasis on molecular pathology of head and neck cancers, particularly examining genetic alterations in salivary gland tumors and their relationship to clinical outcomes. Her work frequently involves collaborative research with clinicians and basic scientists to bridge the gap between pathology findings and clinical management, with notable contributions in areas such as ERBB2 gene copy numbers in salivary duct carcinoma and the PAX3-MAML3 fusion in biphenotypic sinonasal sarcoma.

• Phi Beta Kappa Honor Society Carleton College (1974)
• William Carleton Scholar Carleton College (1974)

Dr. Lewis has demonstrated significant leadership within the Department of Laboratory Medicine and Pathology, serving as Section Head of the Head and Neck Working Group from 2000-2017 and as a member of the Clinical Practice Committee from 2006-2017. Her extensive committee service includes roles on the Workload/Scheduling Team, Part-time Task Force, and Frozen Section Operations Group, reflecting her commitment to improving clinical practice and pathology services.

Through her long-standing membership in professional organizations such as the North American Society of Head and Neck Pathology (since 1997) and the American Academy of Otolaryngology-Head and Neck Surgery (since 1994), Dr. Lewis has significantly contributed to the advancement of her field and the education of future pathologists.