معرفی
Jason Sello is a Professor in the Department of Pharmaceutical Chemistry at the University of California San Francisco (UCSF), holding roles as Vice Dean of Academic Affairs and Executive Committee Member. His research focuses on bacterial proteins, antibiotic resistance mechanisms, and natural product synthesis, particularly targeting pathogens like Mycobacterium tuberculosis and Candida species. He leads efforts in developing proteasome inhibitors and novel antibacterial agents through multidisciplinary approaches.
Key affiliations include the Quantitative Biosciences Institute (QBI) and the Chan Zuckerberg Biohub. His work spans chemical synthesis, microbial genetics, and drug discovery, with contributions to understanding efflux pump mechanisms and retrograde trafficking inhibitors. Notable achievements include the synthesis of cyclomarin natural products and the development of small molecules restoring antifungal efficacy against drug-resistant Candida strains.
His research integrates organic chemistry, microbiology, and pharmacology, addressing challenges in antibiotic resistance and drug delivery. Recent publications highlight in vivo approaches for neuroactive molecules and the mechanistic study of ClpP proteases in tuberculosis. Sello also contributes to institutional leadership, including equity initiatives in pharmacy education and diversity outreach programs.
