Janine Grolleman

Janine Grolleman serves as a Lecturer in Biomedical Engineering at Eindhoven University of Technology (TU/e), focusing on two primary research domains: Cell-Matrix Interactions in Cardiovascular Tissue Regeneration and Modeling in Mechanobiology. Her academic profile demonstrates active research engagement with publications spanning from 2018 to 2025, indicating ongoing contributions to her field.

Her research interests center on cellular mechanobiology with particular emphasis on how cells respond to mechanical stimuli in cardiovascular contexts. Key areas include sprouting angiogenesis, mechanical homeostasis, cytoskeletal dynamics (particularly involving vimentin and actin stress fibers), and the role of Notch signaling in endothelial cell migration under mechanical stress. Her work bridges engineering principles with biological systems to understand fundamental cellular processes.

Analysis of her publication record reveals a consistent focus on developing engineering models to quantify cellular mechanical responses, particularly in vascular contexts. Her research demonstrates progression from fundamental cellular mechanics (2018-2023) toward increasingly sophisticated models for characterizing tissue-level phenomena (2025). A notable pattern is her integration of computational modeling with experimental validation to study how mechanical forces influence cellular behavior during angiogenesis and tissue regeneration.

Grolleman has contributed to multiple research projects resulting in six research outputs between 2018 and 2025, including journal articles and a dissertation. She has collaborated extensively with researchers including Bouten, Sahlgren, and Conte, suggesting participation in established research teams focused on cardiovascular mechanobiology.

Her teaching portfolio includes courses such as 'Engineering organs on a chip', 'Mechanical characterization of materials', and 'Skills - Biomechanics', reflecting the integration of her research expertise into educational activities. The fingerprint analysis of her work identifies key research topics including Rigidity, Vimentin, Stress Fiber, Homeostasis, Actin, Shear Stress, Notch, and Sprouting Angiogenesis, all at significant percentages in Biochemistry, Genetics and Molecular Biology.