معرفی
Jane Jackman is a Professor and Vice Chair for Undergraduate Studies in the Department of Chemistry and Biochemistry at The Ohio State University, College of Arts and Sciences. Her research focuses on mechanistic enzymology and enzyme kinetics of tRNA processing enzymes, particularly tRNAHis guanylyltransferase (Thg1) and tRNA m1G9 methyltransferase (Trm10). She investigates their roles in nucleotide addition, polymerization mechanisms, and biological functions in yeast and other organisms. Her work explores novel enzyme activities and their implications in cellular processes.
Education: B.S. in Biochemistry from the University of Rochester; Ph.D. in Biochemistry from Duke University; postdoctoral research at the University of Rochester School of Medicine.
Research interests include tRNA maturation pathways, reverse polymerase mechanisms, and the evolution of enzymatic functions. Her lab combines yeast genetics, molecular biology, and biochemical techniques to study these enzymes' roles in diverse organisms. Recent studies highlight Thg1's unique 3'–5' polymerase activity and Trm10's substrate specificity across species.
Her contributions span publications on tRNA biogenesis, enzymatic mechanisms, and antibiotic target inhibition (e.g., lipid A biosynthesis). She is affiliated with the Ohio State Biochemistry Program, Molecular, Cell and Developmental Biology (MCDB) graduate program, and the Ohio State University RNA Center.
Labs/Teams: The Jackman Lab focuses on uncovering novel functions of uncommon enzymes and their roles in RNA processing, emphasizing biochemical and genetic approaches to understand fundamental biological processes.
