معرفی
Jan Johannes Doff is a researcher at the University of Groningen's Faculty of Medical Sciences, Department of Pathology, specializing in head and neck oncology and molecular pathology. His work integrates surgical oncology with advanced imaging techniques to improve cancer diagnostics and resection precision.
His research focuses on neoplasm characterization, particularly in oral and salivary gland cancers, utilizing DNA methylation profiling and molecular imaging. Key areas include:
- Head and neck cancer surgical margin analysis
- Salivary gland tumor classification (e.g., Blandin-Nuhn cysts, apocrine carcinomas)
- Fibro-osseous tumor genomics in craniofacial bones
- pH-activatable nanoprobes for fluorescence-guided surgery
Recent publications demonstrate a strong trend toward molecular diagnostics using DNA methylation signatures and copy number alterations for tumor subtyping, with significant contributions to fluorescence-guided oncology through pH-responsive imaging agents. His 2020 Nature Communications paper on metabolic acidosis exploitation has garnered over 137 Scopus citations.
Doff actively collaborates with international surgical oncology groups (e.g., SHINE Study Group) and contributes to clinical pathology journals, with research aligned with UN Sustainable Development Goals for health innovation.
