James W. Mandell

James W. Mandell is a Professor in the Division of Neuropathology at the Department of Pathology, University of Virginia. He serves as a member of the Neuroscience Graduate Program and Associate Director for Curriculum in the Medical Scientist Training Program. His clinical expertise includes surgical and autopsy diagnostic neuropathology, with a focus on neuromuscular and ophthalmic pathology.

• Education:
  • MD/PhD, Cornell University Medical College (1992)
  • Postdoctoral Fellow, University of Virginia Department of Neuroscience (1992–1994)
  • Residency, Anatomic Pathology, University of Virginia (1994–1996)
  • Fellowship, Neuropathology, University of Virginia (1996–1998)

Dr. Mandell's research program centers on biomarker discovery for synaptic degeneration and inflammatory myopathies (e.g., inclusion body myositis), utilizing proteomics and noncoding RNA analysis. He developed a multiplex immunohistochemistry platform (patent pending) for anatomic pathology applications.

His recent publications demonstrate interdisciplinary contributions to CNS lymphatic biology, axonal degeneration mechanisms, and macroglial clearance functions. Collaborative work spans neuro-oncology, neuroimmunology, and diagnostic pathology.