James Van Brocklyn

James Van Brocklyn is an Assistant Professor of Instruction in the Department of Biological Sciences at Ohio University's College of Arts and Sciences. He is based at Irvine 185 on the Athens Campus and is actively involved in undergraduate biology education and research in lipid signaling pathways related to cancer.

• Ph.D., Ohio State University

His primary research interests lie in signal transduction mechanisms mediated by sphingolipids, particularly their roles in brain tumors and cancer progression. He has extensively studied gangliosides and sphingosine-1-phosphate (S1P), showing how these molecules regulate growth factor receptors, cell proliferation, survival, and motility in gliomas. His work bridges lipid biochemistry and oncology, with a focus on identifying molecular drivers of tumor aggressiveness in glioblastoma.

The recent publications highlight a sustained focus on bioactive sphingolipids in neural tumors, particularly their dual extracellular and intracellular signaling functions. His research spans from fundamental receptor interactions to clinical correlations, such as the association between sphingosine kinase-1 expression and poor survival in glioblastoma patients. The work integrates molecular biology, cell signaling, and neuropathology, contributing to both basic science and potential therapeutic targets.

No scientific awards or fellowships are listed in the provided text.

Dr. Van Brocklyn has been deeply involved in teaching and academic mentorship, having taught graduate courses in lipid biochemistry and signal transduction, as well as undergraduate courses including BIOS 1700, BIOS 1030, and laboratory sections. He has led efforts to improve the first-year biology experience through redesigned worksheets and coordination of Peer-Led Team Learning (PLTL) and lab components. While no formal advisees are named, his instructional leadership suggests active student engagement and curriculum development.

He has contributed to collaborative research and authored key publications in journals such as Science, Journal of Cell Biology, and Journal of Neuropathology & Experimental Neurology, indicating involvement in research teams focused on lipid signaling and cancer biology.