James Knight

James Knight, PhD, is a Research Scientist in the Department of Genetics at Yale School of Medicine. He holds appointments in the Yale Center for Genome Analysis and the Yale Center for Genomic Health. His research focuses on genomic and molecular studies in medical genetics, oncology, and developmental disorders. Knight has contributed to over 30 peer-reviewed publications since 2020, including studies on lung cancer immunotherapy resistance, genetic variants in transgender health, and inherited disorders such as Mayer-Rokitansky-Kuster-Hauser syndrome. His work integrates genomic sequencing, multi-omic analysis, and clinical profiling to uncover genetic mechanisms underlying diseases.

Education:

• PhD in Genetics, University of Arizona (1993)
• MS in Genetics, University of Arizona (1989)
• BA in Biology, University of Texas at Austin (1987)

Research Interests:

Dr. Knight’s research spans genetic variants in complex diseases, cancer genomics, and molecular mechanisms of developmental disorders. His lab uses cutting-edge genomic technologies to identify genetic markers and pathways involved in conditions such as meningiomas, cerebral cysts, and autoimmune liver diseases. Collaborations with clinicians and bioinformaticians enable translational studies linking genetic findings to clinical outcomes.

Grants & Awards:

While specific grants are not listed, his publications reflect sustained funding from institutions like the National Institutes of Health and collaborative research networks. He contributed to the CALGB/SWOG clinical trial for colon cancer therapy, indicating involvement in high-impact research initiatives.

Labs & Teams:

He is part of the Yale Center for Genomic Health and collaborates with departments across Yale School of Medicine, including Neurology, Oncology, and Endocrinology. Key collaborators include Murat Günel, Francesc López-Giraldez, and Danielle Miyagishima.