James D Homans

James D Homans, MD is an Associate Professor of Clinical Pediatrics at the University of Southern California and Co-Director of the Maternal Child Adolescent (MCA) Program for Infectious Diseases and Virology at LAC+USC Medical Center. He has served in the Pediatric Infectious Disease Division since 1997 and functions as a principal resource for Los Angeles-area physicians regarding Pediatric Infectious Disease and HIV consultations.

His educational credentials include:

• Combined Medicine/Pediatrics Residency Program, LAC+USC Medical Center (1992)
• Infectious Disease Fellowship, LAC+USC Medical Center (1994)

Dr. Homans' research focuses on congenital cytomegalovirus (CMV) management, HIV care across pregnancy and childhood, and infectious disease diagnostics across all age groups. He maintains active collaborations between Pediatrics, Obstetrics/Gynecology, and Internal Medicine departments to address maternal-fetal transmission challenges and public health crises like congenital syphilis outbreaks. His clinical work emphasizes quality improvement in vulnerable populations through systematic care protocols.

Analysis of his 15 publications (2000-2025) reveals sustained investigation into maternal-fetal HIV transmission mechanisms, antiretroviral pharmacokinetics in neonates, and management of fungal infections in children. Recent work demonstrates particular attention to congenital syphilis care gaps (2025) and antiretroviral-resistant HIV transmission pathways (2024), reflecting his commitment to improving outcomes for high-risk maternal-child dyads.

As Principal Investigator at LAC+USC's MCA Program, Dr. Homans mentors medical students, residents, and mid-level providers while training international physicians in HIV care. His educational leadership spans clinical rotations, didactic instruction, and protocol development for infectious disease management.

He directs a multidisciplinary MCA Program team integrating Pediatric Infectious Disease specialists, OB/GYN clinicians, and Internal Medicine providers to address complex cases involving congenital infections, HIV comorbidities, and antimicrobial resistance across the lifespan.