James C.M. Brust

James C.M. Brust, M.D., is a Professor in the Department of Medicine (General Internal Medicine) at Albert Einstein College of Medicine, based at Montefiore Medical Center. His research focuses on the epidemiology and treatment outcomes of drug-resistant tuberculosis and HIV co-infections in South Africa, with emphasis on novel therapeutics and resistance mechanisms.

Research interests include:

• Transmission patterns of drug-resistant TB
• Pharmacology of TB medications
• Genetic mechanisms of drug resistance
• Integrated treatment models for MDR-TB/HIV

His publications predominantly explore TB/HIV co-infection management, drug efficacy, and resistance mechanisms in South African populations. Recent work emphasizes novel therapeutics like bedaquiline and nanoparticle drug delivery systems.

Dr. Brust has received funding from NIAID to study bedaquiline resistance emergence. He collaborates with international teams on multidisciplinary projects.