معرفی
James C. Lo, M.D., Ph.D., is the Rohr Family Clinical Scholar and Associate Professor of Medicine at Weill Cornell Medical College. As a physician-scientist, he directs a basic research laboratory investigating the molecular basis of cardiometabolic diseases.
- 2023: Rohr Family Clinical Scholar
- 2023: Associate Professor of Medicine, Weill Cornell Medical College
- 2021: Assistant Professor of Medicine, Weill Cornell Medical College
Education:
- 2006 - M.D., University of Chicago Pritzker School of Medicine
- 2004 - Ph.D., University of Chicago
- 1998 - B.S., University of Chicago
Dr. Lo's research focuses on molecular mechanisms of metabolic diseases with emphasis on:
- Cardiovascular biology in diabetes and obesity
- Adipose tissue function and thermogenesis
- Pancreatic islet physiology in metabolic stress
- Inter-organ communication networks
- Novel therapeutic targets for diabetes
- Cardiac complications in metabolic disorders
- Complement system in endocrine regulation
His lab employs single-cell RNA-seq, genetic models, and multi-omics approaches to study:
- β cell subpopulations in diabetes
- Complement receptor signaling
- Adipose-liver-heart cross-talk
- Extracellular vesicle-mediated dysfunction
- Sex-dependent metabolic regulation
Scientific Contributions:
- First to identify adipsin's role in β cell protection
- Discovered complement system's role in islet function
- Defined adipose tissue as SARS-CoV-2 target
- Elucidated mechanisms of obesity-induced arrhythmias
- Developed cross-species models of metabolic stress
Research Funding: Currently holds 8 major grants as Principal Investigator or Key Personnel, including:
- $2.1M - NIH/NHLBI Mechanisms of Obesity-induced Atrial Fibrillation (2025-2028)
- $2.8M - NIH/NIDDK NAD+ Metabolism in β Cell Dysfunction (2025-2030)
- $1.5M - AHA Obesity-Driven Atrial Fibrillation (2024-2027)
- $1.2M - AHA Zebrafish Heart Regeneration (2023-2026)
His laboratory team at the Belfer Research Building (New York, NY) includes post-doctoral fellows, Ph.D. students, medical students, and research technicians working in a collaborative environment.
