معرفی
Jade Wang is a full Professor in the Department of Bacteriology at the University of Wisconsin-Madison. Her research focuses on bacterial stress response mechanisms, particularly how bacteria coordinate cellular processes under environmental stress. She holds prominent positions as a trainer in multiple interdisciplinary graduate programs, including Molecular Biosciences, Genetics, and Cellular and Molecular Biology. Her work integrates genetics, biochemistry, and high-throughput approaches to study signaling networks in model organisms like Bacillus subtilis and E. coli.
Education: B.Sc. Physics (McGill University, 1995), Ph.D. Biochemistry (University of California, San Francisco, 2002), Postdoctoral Research (Massachusetts Institute of Technology).
Research Interests: The lab investigates how bacteria manage metabolic conflicts during stress, focusing on nucleotide signaling molecules like (p)ppGpp and Ap4A. These molecules regulate metabolism, macromolecular machinery coordination, and genome integrity. Key projects include understanding persister cell formation, GTP synthesis via pyruvate kinase, and the interplay between replication and transcription machineries.
Publications: Recent work highlights her lab’s discoveries in persister mechanisms, GTP-driven metabolic control, and mutagenesis from replication-transcription conflicts. Over 50+ publications span Nature Microbiology, mBio, and Current Opinion in Microbiology.
Awards: 2022 Vilas Associate Award, 2018 American Academy of Microbiology Fellowship, HHMI Faculty Scholar (2016), and NIH New Innovator Award (2008).
Lab Team: Includes graduate students (e.g., Jared Brown, Arunima Kalita) and postdocs (e.g., Fukang She, Aude Trinquier), focusing on projects like GTP dynamics and antibiotic resistance. The lab emphasizes interdisciplinary training and collaborative projects.
Future Directions: Extending studies on nucleotide crosstalk, developing tools for single-cell imaging (e.g., mother machine analysis), and applying findings to combat antibiotic resistance in pathogens.
