Jacques Genest

Jacques Genest, MD, FRCP(C), is a Senior Scientist at the Research Institute of the McGill University Health Centre (RI-MUHC) and a Professor in the Department of Medicine at McGill University's Faculty of Medicine and Health Sciences. His research focuses on genetic and metabolic factors in premature coronary artery disease, particularly lipoprotein and apolipoprotein regulation.

Research Initiatives:

• Genetics of low HDL cholesterol states and biogenesis of HDL particles
• Molecular cellular physiology of cholesterol transport
• Cardiology/Prevention Clinic for metabolic and genetic factors in coronary disease
• Founding of the Canadian Familial Hypercholesterolemia (FH) Foundation

Publication Trends: Recent works include clinical trials on anti-inflammatory therapies (Canakinumab), systematic reviews on metabolic syndrome and FH prevalence, and guidelines for dyslipidemia management. Key subfields span inflammation, LDL-C reduction, HDL function, and pharmacological interventions for atherosclerosis.