معرفی
Jacques De Grève is a Physician Scientist at the Vrije Universiteit Brussel (VUB), affiliated with the Department of Medical Genetics at Universitair Ziekenhuis Brussel (UZ Brussel). His primary role combines clinical practice in medical genetics with extensive academic research in oncology and cancer genetics. He has been active since at least 1970, with over 345 peer-reviewed publications and involvement in 60+ research projects focused on cancer predisposition genes, genomic profiling, and molecular oncology.
- Lead researcher in projects addressing pancreatic cancer (e.g., Molecular Portrait of Pancreatic Tumours), lung cancer, and cervical cancer screening programs.
- Member of professional organizations including the Belgian Society of Medical Oncology and European Society for Medical Oncology.
- Supervised 28 academic works, contributing to training in cancer genetics and precision medicine.
Research interests center on uncovering genetic drivers of cancers (e.g., BRCA, RAD17, and ATM mutations), developing targeted therapies (e.g., olaparib, dabrafenib), and advancing genomic profiling techniques for personalized cancer treatment. His work bridges clinical practice and translational research, emphasizing early detection through population screening and molecular tumor boards.
Key contributions include identifying novel cancer predisposition genes and validating diagnostic/therapeutic agents like HER2-targeted PET imaging and BRAF/MEK inhibitor combinations. His interdisciplinary approach integrates genetics, oncology, and clinical medicine to address complex cancer challenges.
