Jack L Feldman

Jack L. Feldman is a Professor of Neurobiology at the University of California, Los Angeles (UCLA), holding the David Geffen School of Medicine Chair in Neuroscience. His research focuses on the neural mechanisms controlling breathing, particularly the role of the preBötzinger Complex in respiratory rhythm generation.

Dr. Feldman's research interests span multiple areas of respiratory neuroscience:

• Neural control of breathing rhythm and pattern
• PreBötzinger Complex function and organization
• Respiratory network dynamics and synchronization
• Effects of opioids and nicotine on breathing
• Interactions between breathing and emotional states
• Neural mechanisms of sighing and other breathing patterns

Analysis of Dr. Feldman's recent publications reveals a strong focus on understanding the microcircuit organization of the preBötzinger Complex, how network synchronization generates breathing rhythms, and how various neuromodulators affect respiratory patterns. His work increasingly integrates computational approaches with experimental neuroscience to understand emergent properties of respiratory networks.

Dr. Feldman has received numerous prestigious awards for his contributions to respiratory neuroscience:

• David Geffen School of Medicine Chair in Neuroscience, UCLA (2022)
• NIH MERIT AWARD (1991-2001)
• NIH Outstanding Investigator Award (2017-2023)
• Hodgkin Huxley Katz Prize from THE PHYSIOLOGICAL SOCIETY (2016)
• Faculty Research Lecture at UCLA (2018)

Throughout his career, Dr. Feldman has mentored numerous graduate students and postdoctoral researchers who have gone on to make significant contributions to neuroscience. His laboratory has been consistently supported by major NIH funding mechanisms, reflecting the importance and impact of his research program. Dr. Feldman has also contributed to collaborative efforts addressing clinical aspects of breathing disorders, including sleep apnea and breathing abnormalities in heart failure patients.

Dr. Feldman leads a vibrant research laboratory at UCLA focused on respiratory neuroscience. His team employs a multidisciplinary approach combining electrophysiology, optogenetics, neuroanatomical tracing, and computational modeling to unravel the complexities of breathing control. The laboratory has made landmark contributions to identifying the preBötzinger Complex as a critical rhythm-generating center for breathing and continues to advance our understanding of how neural networks produce complex physiological outputs.