معرفی
J. Mark Cline, DVM, PhD is a Professor at Wake Forest University School of Medicine with multiple appointments across Comparative Medicine, Pathology, Clinical and Translational Science Institute, Radiation Oncology, and Wake Forest Institute for Regenerative Medicine. He serves as Director of the NIH/NIAID Primate Radiation Survivor Core and Principal Investigator of a DOD/CDMRP Focused Program, while also directing an NIH T32 training program. His extensive affiliations include the Comprehensive Cancer Center, Cardiovascular Sciences Center, Center for Precision Medicine, Hypertension and Vascular Research Center, and Center for Vaccines at the Extremes of Aging.
Dr. Cline earned his BS, DVM, and PhD from North Carolina State University in 1982, 1986, and 1992 respectively, followed by an Anatomic Pathology Residency at New York State College of Veterinary Medicine in 1988. His research program focuses on radiation effects, cancer risk, and progression using experimental models, with particular expertise in nonhuman primate models of cancer and radiation injury.
His laboratory has developed significant expertise in radiation biodosimetry, cancer immunotherapy, and comparative pathology. The Primate Cancer Initiative, which he directs, conducts national outreach to primate research facilities to identify and treat naturally-occurring cancers in nonhuman primates using novel immunotherapy approaches. His work bridges veterinary and human medicine, with high translational value for both human cancer patients and nonhuman primate subjects.
Analysis of Dr. Cline's recent publications reveals a strong focus on radiation biology, particularly in developing biomarkers for radiation exposure assessment and understanding long-term radiation effects on various organ systems. His research integrates molecular biology, comparative pathology, and translational medicine approaches, with a consistent emphasis on nonhuman primate models that provide critical insights applicable to human health.
As a mentor, Dr. Cline has maintained over 25 years of continuous NIH funding and has a documented successful track record of training the next generation of researchers through his NIH T32 program. His laboratory serves as a hub for interdisciplinary research connecting radiation biology, cancer therapeutics, and regenerative medicine.
Dr. Cline directs the J. Mark Cline Lab, which focuses on evaluation of radiation effects and cancer risk through assessment of normal tissues and cancers using various experimental models. His work with the Primate Radiation Survivor Core represents a unique national resource for studying radiation effects in nonhuman primates, supporting research across multiple institutions and disciplines.
