Isidore Rigoutsos

Dr. Isidore Rigoutsos serves as the Richard W. Hevner Professor in Computational Medicine at the Department of Pathology & Genomic Medicine and directs the Center for Computational Medicine. His work intersects computational biology and clinical applications, focusing on RNA regulatory mechanisms.

• Contact: 1020 Locust Street, Jefferson Alumni Hall, Philadelphia, PA 19107
• Phone: 215-503-6152 | Fax: 215-955-5058

Research interests span non-coding RNA biology, including:

• miRNA/piRNA targeting in cancer and disease
• RNA-seq analysis across biofluids and cell types
• Health disparities linked to RNA fragmentation patterns
• Hospital RNA diagnostics and therapeutic development

His publications emphasize small RNA profiling in diverse conditions (e.g., ALS, TNBC, uveal melanoma) and computational tools like MINTmap, YAMAT-seq, and CorrAdjust. Key contributions include databases for RNA fragments and race/sex-specific RNA patterns in health disparities.

Dr. Rigoutsos leads the Computational Medicine Center and maintains affiliations with the College of Life Sciences, driving interdisciplinary research in RNA-based medicine.