Isabelle Rapin

The Isabelle Rapin Division of Child Neurology at Montefiore Einstein focuses on advancing treatments for childhood neurological diseases through translational and basic science research. The division collaborates closely with the Albert Einstein College of Medicine and the Laboratory of Developmental Epilepsy, leveraging unique patient populations and state-of-the-art methodologies to develop innovative therapeutic strategies.

• Epilepsy Center: Investigates mechanistic target-based treatments, biomarkers, and computer-based EEG analyses for drug-resistant epilepsies.
• Neuromuscular Center: Implements newborn screening for spinal muscular atrophy and prompt treatments.
• Headache Center: Develops novel therapies for pediatric migraines and rare headache conditions.
• Rett Syndrome Tristate Center: Provides clinical care, education, and research toward cures.
• Neuro-oncology: Partners with Pediatrics to address childhood neurological cancers.
• Neurocutaneous Disorders Center: Conducts drug trials and therapies for diseases affecting both nervous system and skin.

Key research initiatives include:

• EpiBioS4Rx: Studies biomarkers for post-traumatic epileptogenesis using cEEG and depth EEG.
• FEBSTAT: Tracks EEG, MRI, and clinical outcomes after febrile status epilepticus.
• Learning Healthcare System: Aggregates clinical data to improve pediatric epilepsy care.
• Rare Epilepsies CDC Grant: Analyzes epidemiological data to guide research and care.
• Human Epilepsy Project: International collaboration for treatment-resistant epilepsy.

Clinical trials focus on novel antiseizure medications like Carisbamate and XEN1101 for Lennox Gastaut syndrome and focal-onset seizures.