معرفی
Dr. Isabel Mellon is an Associate Professor and Director of Graduate Studies in the Department of Toxicology and Cancer Biology at the University of Kentucky. She holds a PhD from the University of Illinois Chicago and completed postdoctoral training at Stanford University. Her research focuses on DNA repair mechanisms, particularly nucleotide excision repair (NER), and its role in disease processes like cancer and aging. Current projects investigate individual variations in NER efficiency as cancer predictors, tobacco smoke's inhibition of NER in lung cells, and NER's influence on chemotherapy efficacy.
- Education: PhD in [field] from University of Illinois Chicago; Postdoc at Stanford University
Her work combines molecular biology techniques with clinical relevance, addressing how environmental toxins and genetic factors interact to impact health outcomes. She leads a laboratory exploring NER's dual subpathways (transcription-coupled repair and global genome repair) and their implications for disease etiology.
Key findings include demonstrating that tobacco smoke components inhibit NER pathways, amplifying carcinogenic risk, and identifying arsenic's role in suppressing XPC protein expression critical for DNA repair. This research bridges basic science with translational applications in precision medicine and public health.
