معرفی
Isaac T Schiefer is a Professor in the Department of Medicinal and Biological Chemistry at the University of Toledo College of Pharmacy and Pharmaceutical Sciences. He serves as Director of the Center for Drug Design and Development (CD3) and Associate Director of the Shimadzu Laboratory for Pharmaceutical Research Excellence.
- Research Focus: Neuropharmacology, drug design, nitric oxide mimetics, zebrafish models, and gut-brain axis interactions
- Key Techniques: Photoaffinity labeling, LC-MS metabolomics, neurobehavioral analysis
His recent work examines:
- Allosteric modulation of M1 receptors in zebrafish neurotoxicity
- Impact of gut bacterial short chain fatty acids on cardiovascular function
- Hybrid NO mimetics for neurodegenerative diseases
- SPC toxicity mechanisms using zebrafish models
- Pharmacokinetics of brain-penetrant compounds
Publications demonstrate expertise in:
- Drug metabolism via sulfotransferases
- Neuroprotective agent development
- Pharmaceutical microbiome interactions
- Calpain inhibition for Alzheimer's disease
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