معرفی
Isaac Samuel Kohane, MD, PhD, is the inaugural Chair and Marion V. Nelson Professor of Biomedical Informatics at Harvard Medical School, with additional appointments as Professor of Pediatrics at Boston Children's Hospital and Associate Professor of Medicine at Brigham and Women's Hospital. He directs the Kohane Lab ('Zaklab'), pioneering AI integration in clinical medicine, patient data control, and human values in AI systems.
His research spans 30+ years of re-engineering healthcare through computational techniques, linking EHR and genomic data to study complex diseases like autism, cancers, and rare disorders. He co-authored the Institute of Medicine's Precision Medicine Report and authored influential books including The AI Revolution in Medicine.
Recent work focuses on causal machine learning for treatment outcomes, GPT-4 applications in diabetes monitoring, and patient-centric data systems like PING and Guardian Angel. He leads NIH-funded initiatives on trans-omics integration (TOPMED) and patient-centered information commons.
- Scientific Honors:
- Institute of Medicine (National Academy of Medicine) member
- American Society for Clinical Investigation member
- Current Research:
- Multi-institutional real-world data pipelines
- AI ethics and value alignment
- Genomic risk scores in cancer
- Neurodevelopmental disorder genetics
The lab fosters a collaborative environment with graduate students and postdocs working on large language models, precision oncology, and disease classification. He balances leadership in NEJM AI as Editor-in-Chief with hands-on research and mentorship.
