معرفی
Irina Gazaryan is a Lecturer in the Department of Chemistry/Physical Sciences at Dyson College of Arts and Sciences, Pace University, where she contributes to both teaching and biochemical research. She holds a PhD in Chemistry/Biochemistry from Lomonosov Moscow State University, Russia, with a specialization in Chemical Enzymology.
Research Interests: Her research is centered on neuroprotection, focusing on the activation of endogenous antioxidant and antihypoxic genetic programs. She has pioneered the development of two luciferase-based reporter systems—patented Neh2-luc and optimized HIF ODD-luc—for high-throughput screening of novel activators. These tools enable detailed structure-activity relationship studies using 2D-titration methods to uncover the molecular mechanisms of candidate compounds.
Publication Trends: Her recent publications (2020–2023) reflect a strong focus on enzyme kinetics, hypoxia response pathways, and pharmacological modulation of oxidative stress. These works span applications in cancer therapy, neuroprotection, and even potential repurposing of HIF modulators for viral infections like COVID-19. The interdisciplinary nature of her research bridges biochemistry, pharmacology, and materials science, particularly in drug delivery systems.
- Scientific Awards: No awards mentioned in the provided text.
Advising and Grants: While no formal students or grant funding are listed, she has supervised research courses such as BMB 711 and CHE 480, indicating involvement in student research mentorship. She likely participates in collaborative research projects, as evidenced by co-authorship with teams involving Kazakov, Thomas, and Poloznikov.
Labs and Teams: Her work appears to be conducted in collaboration with a multidisciplinary research group focused on enzyme mechanisms, redox biology, and therapeutic development. She has presented at conferences like PITTCON and contributed to studies involving lipobeads for anticancer drug delivery, suggesting active participation in a dynamic research environment.
