Inmaculada Martínez Reyes

Dr. Inmaculada Martínez Reyes serves as a Young Investigator Group Leader at Charité – Universitätsmedizin Berlin under the German Cancer Consortium (DKTK). She directs the "Metabolic Networks in Tumor Immunity" research group, focusing on the critical interplay between cancer cell metabolism and immune system regulation within the tumor microenvironment.

Her research centers on three core questions: how cancer cells rewire metabolism to evade immune detection, how metabolic pathways regulate T cell tumor infiltration/exhaustion, and mitochondrial mechanisms supporting anti-tumor T cell functions. This work identifies metabolic vulnerabilities for enhancing immunotherapy efficacy, particularly through nutrient competition dynamics and metabolite-mediated immune suppression in tumors.

Analysis of her 9 publications (2016-2024) reveals consistent emphasis on mitochondrial metabolism as the central theme. Key discoveries include mitochondrial ubiquinol oxidation's necessity for tumor growth (Nature 2020), TCA cycle metabolites' regulatory roles, and metabolic reprogramming impacts on proteostasis. Her work bridges fundamental mitochondrial biology with translational cancer immunology, highlighting metabolic pathways as therapeutic targets.

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Dr. Martínez Reyes leads the DKTK-affiliated "Metabolic Networks in Tumor Immunity" group at Charité, employing molecular and cellular approaches to dissect metabolic crosstalk between cancer and immune cells. Her team's work directly addresses therapeutic limitations in current immunotherapies through mechanistic exploration of metabolic immune evasion.