معرفی
Indrajeet Sharma is an Associate Professor in the Department of Chemistry and Biochemistry at the University of Oklahoma. His research focuses on synthetic organic chemistry, natural product-inspired drug discovery, and sustainable chemical methodologies. He leads the Sharma Laboratory, which develops novel chemical transformations using Earth-abundant metals and applies them to synthesize complex natural products for pharmaceutical applications.
- Education:
- B.S., University of Delhi, India (2004)
- M.S., Indian Institute of Technology Kharagpur, India (2006)
- Ph.D., Wayne State University (2011)
- Postdoc, Memorial Sloan-Kettering Cancer Center (2011-2014)
Research interests include synergistic catalysis with metal carbenes, carbohydrate chemistry, and mitigating greenhouse gases (N₂O and CH₄) through conversion into value-added chemicals. Key projects involve developing non-addictive painkillers inspired by natural products like collybolide and creating cascade reactions for bioactive scaffolds.
Recent publications emphasize stereoselective glycosylation methods, sulfenylnitrene-mediated functionalizations, and iron/copper-catalyzed transformations. The lab collaborates with the Institute for Natural Products Applications and Research Technologies (INPART) to advance drug discovery pipelines.
Grants and projects include NSF CAREER funding for stereoselective carbene cascade cyclizations and NIH support for antibiotic discovery. The lab employs interdisciplinary approaches combining organic synthesis, medicinal chemistry, and sustainability to address unmet biomedical needs.
