Ilan Azuelos

Ilan Azuelos is an Assistant Professor at the Department of Medicine, Faculty of Medicine and Health Sciences, McGill University, and an Investigator at the RI-MUHC, Glen site within the Translational Research in Respiratory Diseases Program. His research focuses on the molecular mechanisms underlying lung fibrosis, particularly the role of myofibroblasts and the mTOR pathway in metabolic reprogramming for collagen biosynthesis, a field he has termed fibrometabolism.

Research Trends

• Key themes include TGF-β signaling in fibrosis
• Metabolic pathways in myofibroblast activation
• ACE2/Ang-(1-7)/MasR axis in COVID-19-related fibrosis
• Role of RNA-binding protein HuR in lung fibroblast differentiation
• Mitochondrial dynamics in ventilator-induced diaphragmatic dysfunction
• Interdisciplinary links between respiratory medicine, cell biology, and metabolic disorders

Publications

• 2023: Semionov et al. - Radiological analysis of pulmonary calcification in central pulmonary embolism
• 2022: Martin et al. - Debate on HB-EGF origin in fibrosis
• 2021: Selvarajah et al. - mTORC1's role in serine-glycine pathway for collagen
• 2021: Morganstein et al. - ACE2 axis in pulmonary fibrosis and COVID-19
• 2021: Al-Habeeb et al. - HuR's impact on extracellular matrix production
• 2021: Trivlidis et al. - HuR activation under hypoxia in fibroblasts
• 2019: Selvarajah et al. - mTORC1 and glycine metabolism in fibrosis
• 2018: Liang et al. - Ventilator effects on diaphragm dysfunction in MDX mice
• 2015: Picard et al. - Mitochondrial abnormalities from mechanical ventilation
• 2015: Azuelos et al. - Autophagy's role in ventilator-induced diaphragm dysfunction