Hui-Zi Chen

Dr. Hui-Zi Chen is an Assistant Professor at the Medical College of Wisconsin and a practicing Medical Oncologist specializing in thoracic malignancies at Froedtert Hospital. She holds an MD and PhD from The Ohio State University, where she completed residency, fellowship, and postdoctoral training in Molecular Virology, Immunology, and Medical Genetics.

Research Focus

Her research integrates clinical oncology with genomics to develop precision therapies for advanced solid cancers. Key areas include:

• Translational genomics and biomarker discovery in lung cancer
• Immunotherapy resistance mechanisms and PD-1/PD-L1 biology
• Tumor-agnostic targets (e.g., ALK fusions)
• Implementation of germline testing in cancer care

Publication Trends

Dr. Chen's 12 recent articles (2021-2025) demonstrate a focus on precision oncology, with themes spanning clinical trials (tarlatamab, belzutifan), transcriptomic analyses (PD-1 across cancers), and molecular characterization of resistance mechanisms. Her work consistently bridges basic science with clinical applications.

Clinical Practice

She treats adults and seniors with lung cancer and other thoracic malignancies, utilizing chemotherapy, immunotherapy, targeted therapy, and cellular therapy. She is fluent in English and Mandarin Chinese.