Huaiyu Mi

Huaiyu Mi is an Associate Professor in the Department of Population and Public Health Sciences at the University of Southern California (USC). His research focuses on bioinformatics, genomics, and systems biology, with a strong emphasis on developing computational tools and databases for functional genomics. He is a key contributor to major resources such as InterPro, PANTHER, and the Gene Ontology (GO), which provide critical annotations for protein families, gene functions, and biological pathways. His work integrates phylogenetic analysis, machine learning, and statistical methods to advance understanding of gene function and genomic data interpretation. Mi has also contributed to systems biology initiatives, including the development of standardized graphical notations for biological processes.

His research interests span protein domain classification, polygenic risk scoring, and the analysis of gene-environment interactions. He has authored numerous publications on topics such as enhancer-gene regulatory relationships, automated gene function annotation, and the convergence of pathway databases. Mi's contributions to bioinformatics tools like AnnoQ and PEREGRINE highlight his commitment to making genomic analysis accessible to researchers worldwide. His work has implications for precision medicine, genetic epidemiology, and the broader study of biological systems.

Mi holds a PhD and has been affiliated with USC since joining the faculty. His academic activities include advising on interdisciplinary projects at the intersection of computational biology and health sciences.