معرفی
Hong Zhang is an Associate Professor at the University of Massachusetts Chan Medical School, affiliated with the T.H. Chan School of Medicine and the Department of Pediatrics. His research focuses on the genetic regulation of senescence in cancer, aging, and stem cell self-renewal, alongside molecular targeting of E3 ligases in transcriptional regulation. He holds the title of New Scholar in Aging of the Ellison Medical Foundation and leads the Zhang Lab, which investigates senescence mechanisms in tumors and aging processes.
Education: B.S. in Biology from Fudan University (China), Ph.D. in Genetics from Michigan State University, and postdoctoral training at Stanford University School of Medicine.
Research Interests: Genetic pathways of senescence, senescence's role in oncogenesis (e.g., Smurf2-deficient mouse models), and senescence regulation in aging and stem cell function. The lab explores how E3 ligases like Smurf2 influence transcription factors and ubiquitination in diseases like cancer.
Publications highlight studies on Smurf2’s role in tumor suppression, hematopoietic stem cell dynamics, and molecular mechanisms of senescence. Awards include the Ellison Medical Foundation New Scholar award.
Labs/Teams: Zhang Lab at UMass Chan Medical School, focusing on cellular senescence and E3 ligase biology.
