Hollis Cline

Hollis Cline, PhD, is the Hahn Professor of Neuroscience and Director of the Dorris Neuroscience Center at The Scripps Research Institute (TSRI). She holds adjunct positions at the University of California San Diego and the Salk Institute. Her research focuses on understanding how sensory experience shapes visual circuit development, plasticity, and function, with a focus on neurodevelopmental disorders. Cline earned her PhD in Neurobiology from UC Berkeley (1985) and conducted postdoctoral work at Yale and Stanford. She has served in leadership roles including Co-Chair of TSRI’s Department of Neuroscience and President of the Society for Neuroscience (2015–2016).

Her research integrates molecular genetics, electrophysiology, and imaging to study structural dynamics in neural circuits, neurogenesis regulation, and excitation/inhibition balance. Key projects include the Dynamic Connectome (3D connectomics in the optic tectum), neurogenesis control, and the role of inhibition in visual circuit function. Her work revealed activity-dependent mechanisms driving synaptic maturation and topographic map formation, and identified molecular pathways linking visual experience to brain development.

• Education: PhD (UC Berkeley), B.A. (Bryn Mawr College)
• Awards: NIH Pioneer Award, AAAS Fellow, TSRI Mentor Award
• Labs/Teams: Cline Lab at TSRI, Dorris Neuroscience Center
• Grants: Not explicitly listed but implied via NIH advisory roles and research infrastructure
• Professional Service: NINDS Board, NIH Advisory Council, Society for Neuroscience leadership

Her recent work bridges neurodevelopmental mechanisms with translational insights, using Xenopus models to study exosome-mediated intercellular communication and regeneration responses to injury. Collaborative efforts include the BigNeuron project for neuronal morphology analysis and AI-driven behavior recognition studies.