Hideki Ukai

Hideki Ukai, Ph.D., is a Project Associate Professor at The University of Tokyo and Core Manager of the ES-Mouse/Virus Core facility. His research focuses on developing next-generation mammalian genetic technologies for organism-level systems biology, enabling high-throughput analysis of human gene networks and cellular circuits through genetically humanized mice. Previously, he held positions at RIKEN QBiC (Senior Researcher), RIKEN CDB (Researcher), and National Institute of Radiological Sciences (Postdoctoral Researcher).

His work spans systems biology of circadian clocks, reverse genetics, and innovative mouse model production without traditional crossing. Key contributions include single-generation knock-in mouse protocols, temperature-insensitive circadian phosphorylation mechanisms, and CRISPR-based knockout-rescue strategies. Recent studies explore sleep-wake cycle regulation via kinase-phosphatase competition and anesthesia's molecular effects on circadian systems.

Scientific awards and honors are not explicitly mentioned in the provided materials. His publication trends emphasize circadian clock dynamics, genetic engineering innovations, sleep regulation biochemistry, and humanized mouse models for systems-level biological analysis.