Hideho Okada

Hideho Okada is a Professor of Neurosurgery at the University of California San Francisco (UCSF) and a member of the Parker Institute for Cancer Immunotherapy. As a physician-scientist with over 25 years of experience, his work focuses on immune mechanisms in brain tumors and novel immunotherapy strategies.

• M.D. and Ph.D. from Nagoya University School of Medicine
• Leader in glioma immunotherapy research
• Developed 8 FDA-approved investigational drugs

His research includes:

• Discovery of CTL epitopes in glioma-associated antigens
• Development of CAR-T therapies targeting EGFRvIII and H3.3K27M mutations
• iRANO criteria for immunotherapy response evaluation

Recent work emphasizes overcoming antigen heterogeneity and T-cell exhaustion through synNotch-primed CAR systems. Funding includes multiple NIH grants. Awards highlight his translational and team science contributions.