Hervé Le Hir

Hervé Le Hir is a Professor at the Department of Biology of École Normale Supérieure (ENS), leading a research team focused on post-transcriptional regulation of gene expression, particularly the Exon Junction Complex (EJC). His work integrates biochemistry, biophysics, and transcriptomics to study EJC assembly, dynamics, and roles in mRNA transport, translation, and quality control. He has contributed to resolving the EJC core structure, identifying its role in NMD and translational activation, and mapping its genome-wide binding sites in human cells.

• Research Themes: RNA-protein interactions, molecular motors, mRNA metabolism, EJC function, NMD pathway.
• Key Methods: Protein reconstitution, single-molecule biophysics, CLIP-seq, high-throughput sequencing.

Recent studies include exploring EJC-dependent mRNA localization in ciliogenesis and characterizing UPF1 helicase activities. His lab actively recruits researchers and can be contacted directly for collaboration.