Hermann von Grafenstein

Hermann von Grafenstein is an Associate Professor in the Department of Medicinal and Biological Chemistry at the University of Toledo's College of Pharmacy and Pharmaceutical Sciences. His research focuses on immune response mechanisms in both innate and adaptive immunity, particularly antigen presentation processes and their implications for inflammatory diseases and vaccine development.

• Education:
  • Ph.D. in Biophysical Chemistry, Max Planck Institute of Biochemistry & University of Konstanz (1983)
  • M.D., University of Munich (1982)
  • M.S. in Physics, University of Munich (1976)
• Research Themes:
  • Antigen Presentation
  • Toll-like Receptor Signaling
  • MHC-Peptide Interactions
  • Water Network Dynamics
  • Inflammatory Disease Mechanisms
  • Vaccine Development
• Publication Trends:
  • Recent work investigates obesity-related immune interactions (2014)
  • Structure-function analysis of MHC complexes (2014-2000)
  • TLR4 activation mechanisms in atherosclerosis (2006)
  • Computational modeling of immune responses (2006-1999)
• Scientific Techniques:
  • X-ray Crystallography
  • NMR Spectroscopy
  • Hydrogen-Deuterium Exchange
  • Molecular Modeling