معرفی
Hayarpi Mantashi Simonyan serves as Head of Department and Associate Professor at Yerevan State University's Institute of Pharmacy, Department of Pharmacochemistry and Pharmacognosy. Her academic leadership spans institutional roles including membership in YSU's Scientific Council (2015-2023) and chemistry expertise for EU4INNOVATION projects (2019-2022).
- Yerevan State University, Faculty of Chemistry (2001-2006): Certified Specialist
- Yerevan State University (2014): Candidate of Sciences in Chemical Sciences
Her research centers on asymmetric synthesis of non-protein amino acids with therapeutic applications. Current investigations focus on G-quadruplex DNA binding compounds for anticancer activity, neuroprotective phytochemicals for Alzheimer's disease, and thioxo-triazole-bearing dipeptides with ROS-scavenging properties. Her work bridges organic synthesis with biological evaluation, emphasizing structure-activity relationships in amino acid derivatives.
Analysis of her 15 most recent publications reveals dominant trends in anticancer drug development (47% of articles), neuroprotective compound research (13%), and novel synthetic methodologies (40%). Key subfields include G-quadruplex DNA targeting, alkyne-functionalized amino acids, and heterocyclic triazole derivatives, demonstrating consistent specialization in bioactive non-proteinogenic amino acids.
- State Prize in exact and natural sciences (2015) for 'Efficient small-scale production technology of new generation non-protein amino acids'
Simonyan maintains active international collaborations including joint programs with Peoples' Friendship University of Russia and research cooperation with Naples' Institute of Biostructures and Bioimaging. Her grant portfolio includes EU4INNOVATION project funding (2019-2022) and multiple conference participations across 8 countries, reflecting strong transnational research engagement. Leadership extends to heading Armenia's Young Chemists Association (2013-2023) and Armenian Association of Biotechnologists (2014-2023).
She directs the Department of Pharmacochemistry and Pharmacognosy research group, focusing on synthetic amino acid chemistry with applications in oncology and neurodegenerative diseases. Current projects involve molecular design of G-quadruplex binders and clove-derived neuroprotectants, with emphasis on translational pharmaceutical development.
