معرفی
Harvey Friedman is a Professor of Medicine (Infectious Diseases) at the Perelman School of Medicine, University of Pennsylvania. His research focuses on developing vaccines for genital herpes caused by HSV-1 and HSV-2, with particular emphasis on understanding and counteracting viral immune evasion strategies through glycoproteins gC and gE.
- Education: B.S. and M.D. from McGill University (1965, 1969)
Research Interests include:
- Vaccine design using nucleoside-modified mRNA in lipid nanoparticles
- Targeting HSV glycoproteins gC, gD, gE to block viral entry and immune evasion
- Preclinical models (mice, guinea pigs, rhesus macaques) for vaccine testing
- Therapeutic applications for reducing outbreak frequency in infected individuals
- Complement system interactions with HSV pathogens
Selected Publications demonstrate:
- Trivalent mRNA vaccines achieving 50-100x reduced virulence in animal models
- Key insights into HSV immune evasion mechanisms via gC/gE
- Transition to human clinical trials by 2022 for prevention
- Expanding vaccine applications to oral herpes and neonatal protection
Lab Personnel include:
- Dr. Sita Awasthi (Research Associate Professor)
- Dr. Lauren M. Hook (Research Assistant Professor)
- Dr. Kevin Egan (Post-doctoral Fellow)
- Dr. Angela Desmond (Instructor in Pediatric Infectious Disease)
- Dr. John Lubinski (Senior Research Scientist)
- Bernard Fowler (Research Specialist)
- Zauraiz Syeda (Research Specialist)
- Valerie Bromberg (Undergraduate researcher)
Current projects evaluate mRNA vaccine efficacy against neonatal herpes, therapeutic applications for outbreak reduction, and cross-protection against oral herpes infections.
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