Harry P.W. Kozakewich

Harry P.W. Kozakewich, MD, is Professor of Pathology at Harvard Medical School and practices at Boston Children's Hospital within the Department of Pathology. He specializes in pediatric pathology with a focus on vascular malformations, hemangiomas, and oncologic pathology. His clinical work and research center on characterizing vascular anomalies and developing diagnostic approaches for pediatric tumors.

Education:

• Medical School: University of Saskatchewan College of Medicine (1967)
• Internship: Saint Boniface Hospital (1968)
• Residencies: Diagnostic Radiology (New York Hospital-Cornell Medical Center, 1971), Pathology (Boston City Hospital, 1972, 1976), Anatomic Pathology and Diagnostic Radiology (Boston Children's Hospital, 1975)
• Fellowship: Oncologic Pathology, Sloan-Kettering Memorial Hospital (1978)

Research Focus: Dr. Kozakewich's work explores the molecular mechanisms underlying vascular anomalies, including hemangiomas and lymphatic malformations. His investigations span genetic drivers (e.g., GNAQ/GNA11 mutations), endothelial cell biology, and preclinical models to identify therapeutic targets. His recent studies emphasize mevalonate pathway dysregulation in infantile hemangiomas and mutation-specific pathology in capillary malformations.

Publication Trends: His recent articles (2020-2025) demonstrate a focus on genetic characterization of vascular anomalies, immunohistochemical markers for diagnosis, and mechanistic insights from animal models. Key themes include somatic mutations in vascular tumors, lymphatic malformation pathology, and clinical-pathological correlations for rare pediatric conditions.

Certifications:

• American Board of Pathology (Anatomic Cytopathology)
• American Board of Radiology (Diagnostic Radiology)