Hardy Kornfeld

Hardy Kornfeld, MD is a Professor at the University of Massachusetts Chan Medical School, affiliated with the T.H. Chan School of Medicine's Department of Medicine. He also holds positions in the Morningside Graduate School of Biomedical Sciences across multiple programs, including Immunology and Microbiology, Interdisciplinary Graduate Program, and MD/PhD Program.

Education: BA in Liberal Arts from Bennington College (VT), MD from Boston University School of Medicine (1978). Clinical training includes medical residency at University Hospital (Boston), St. Luke's Hospital (NY), and specialized fellowships in Infectious Disease, Pulmonary Medicine, and Molecular Virology at institutions including Harvard School of Public Health.

Research focuses on tuberculosis (TB) pathogenesis, host immune responses, and the impact of metabolic disorders like diabetes on TB outcomes. Key interests include macrophage apoptosis in TB defense, diabetes-TB comorbidity mechanisms, IL-16's role in immunity, and heterologous immunity between viruses and mycobacteria.

Publications emphasize clinical and translational research, with recent work on post-TB lung disease, metformin's therapeutic potential in TB-diabetes comorbidity, and biomarkers predicting TB treatment outcomes. Collaborative studies involve multinational cohorts in India and Georgia.

Notable contributions include defining diabetes as a risk factor for adverse TB outcomes and exploring host metabolic pathways influencing TB susceptibility. Research has implications for global TB control strategies and comorbidity management.