Haolong Li

Haolong Li, PhD, serves as Assistant Professor in the Human Biology Division at Fred Hutchinson Cancer Center (Fred Hutch), where he investigates molecular networks driving advanced prostate cancer progression through innovative genomic approaches.

His academic credentials include:

• PhD, University of British Columbia, 2017
• MSc, Jilin University, 2010
• BSc, Jilin University, 2009

Research focuses on three interconnected pillars:

• Androgen Receptor Regulation: Identification of novel AR signaling regulators (e.g., PTGES3) via endogenous reporter CRISPRi screens
• Lineage Transition Mechanisms: Molecular determinants of AR-dependent to AR-independent state transitions using perturb-seq and multiplex-guide RNA
• Immunotherapy Targets: Discovery of immune checkpoint mediators through solid tumor/immune cell co-culture screening

Affiliated with the Fred Hutch Prostate Cancer Program, his lab integrates cancer cell biology, immunology, and genomic technologies to translate findings into clinical applications for overcoming therapeutic resistance.